Our Paper Published in Microfluidics and Nanofluidics

We are pleased to share that our latest work has been published in Microfluidics and Nanofluidics. The study reveals that fluidic shear stresses can significantly enhance the virulence of Klebsiella pneumoniae, independent of nutrient conditions. By exposing bacteria to controlled shear rates in microchannels, we observed a 20–50% increase in intracellular proliferation within macrophages, with shear rate emerging as the dominant factor over nutrient availability. These findings challenge conventional understanding and highlight how mechanical cues in flowing fluids can directly reprogram bacterial behavior, with important implications for the design of medical devices, bioreactors, and organ-on-a-chip systems to mitigate infection risks. Visit - https://lnkd.in/gQitZMfW